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A large randomized trial in older adults found no effect of EPA and DHA on cognitive function, and the broader trial record shows little benefit in cognitively healthy people or in established Alzheimers, with a possible signal in early cognitive impairment and in people who do not carry APOE4

PlexusDx also offers the optional Precision Peptide Genetic Test ($99 add-on after the first month) to identify genetic predispositions affecting GLP-1R and GIPR signaling, helping determine whether tirzepatide is optimally suited to your biology

The researchers note that about a quarter of those on the lowest dose of these medications gained weight

While headache predisposition is not a single genetic trait, understanding your overall receptor sensitivity and metabolic profile helps your PlexusDx care team personalize your dosing from day one, potentially reducing side-effect burden