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475,476 The relationship between integrins and the ECM is highly dynamic and regulated by several mechanisms, including conformational changes of integrins, which can switch between inactive and active states

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Human studies support these findings: A randomized controlled trial demonstrated that a six-month zinc supplementation regimen in older adults increased plasma zinc levels and decreased markers of inflammation, including high-sensitivity C-reactive protein, IL-6, MCP-1, and VCAM-1