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The most common ones included: Nausea (17.3% of subjects) Diarrhea (11.6%) Vomiting (10.1%) Nasopharyngitis (6.2%) Dyspepsia (2.8%) Gallbladder-related events (1.6%) Acute pancreatitis (0.5%) The discontinuation rate at the highest dose was 8.5% [18]

These results may be explained by several known physiological mechanisms of oral water