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When we consume large amounts of sugar, the pancreas has to release larger amounts of insulin to bring the levels of sugar in the blood back down

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Its simultaneous activation of three receptor pathways GLP-1R for appetite suppression and insulin secretion, GIPR for augmented insulin response and central appetite modulation, and GCGR for energy expenditure and hepatic fat mobilisation produces metabolic effects that exceed what single or dual agonism can achieve [4][8][9]

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