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The GSDMD pores in the membrane will collapse ion gradients and lead to an influx of water, ultimately resulting in ninjurin 1 (NINJ1)-dependent cell membrane rupture and the release of DAMPs [122]

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The formulation also exhibited high drug loading efficiency (74.65%), stable physicochemical properties across gastrointestinal pH conditions for at least 14 days and excellent in vitro biocompatibility over a wide concentration range (0120 M)

Although exact mechanisms remain unclear, the blend continues to attract attention in laboratories investigating peptidereceptor interactions