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19 :1-5 Key words: type 2 diabetes, cardiovascular outcome studies, pioglitazone, SGLT2 inhibitors, GLP-1 receptor agonist In previous editorials 1-4 we proposed that metformin, pioglitazone, sodium glucose transporter 2 (SGLT2) inhibitors (in particular empagliflozin and canagliflozin) and long-acting glucagon-like peptide-1 (GLP-1) receptor agonists (in particular liraglutide) in combination could complement each other to prevent cardiovascular events and save lives in patients with type 2 diabetes at high cardiovascular risk

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The peptides will be reviewed by the Pharmacy Compounding Advisory Committee (PCAC), with consideration scheduled for the meeting on 2324 July 2026 or by February 2027

injectable routes amount adjustments required for comparable systemic exposure Individual variability in gastrointestinal physiology affects absorption Food effects and gastric emptying rate influences First-Pass Metabolism: Hepatic first-pass extraction reduces systemic availability May generate different metabolite profiles vs