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doi: 10.1038/nrendo.2018.24 11 MoranLJKoHMissoMMarshKNoakesMTalbotMet al

Students t test and Fischer exact test were used to compare type 2 diabetes vs NGT, and paired t tests were used to compare pre vs post metformin

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In this work, we investigate the molecular mechanisms by which GLP-1, oxyntomodulin, exendin-4, and exendin-P5 bind and activate the GLP-1R using a combination of structural biology, molecular dynamics simulations, and pharmacological studies combined with extensive receptor mutagenesis