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The side effects of the combination GLP - 1/GIP are similar to that of GLP - 1, and careful titration and monitoring is required with both medications

(From the name, it can act like insulin.) Edema (swelling) Joint pain Cardiovascular (heart) effects Increased intracranial pressure Unknown long-term health or psychiatric effects For teens with depression or bipolar disorder (often not yet recognized in teens), IGF-1 is especially concerning

Science 387 , 329336 (2025)

This article clarifies the fundamental differences between berberine and prescription GLP-1 medications, examines the evidence, and outlines important safety considerations for UK patients