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However, mAb treatment tended to oppose age-related changes in 30 of these metabolites (22 marginally significant after FDR correction), including a reduction in the age-related rise of many glycerophospholipids, and a distinct clustering of metabolites from heart tissue in Old Con versus Old mAb-treated animals by PCA (Supplementary Fig

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In order to collect a sufficient number of cells for implantation, isolated chondrocytes usually undergo an extensive expansion from 0.10.2 million to 4060 million ( Thus, selectively removing senescent cells in chondrocytes is crucial to assure the quality of cells for ACI

83 For oral administration, dosages were in the range of 7501500 g per day for 12 weeks to 1 year