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Furthermore, the secretome of hMSC-Ex-4 displayed an altered protein profile, including enhanced secretion of insulin-like growth factorbinding protein 2 (IGFBP2) and apolipoprotein M (APOM), both of which are implicated in metabolic regulation and may contribute to the therapeutic modulation of type 2 diabetes mellitus [18]

Since then, its popularity has increased as more and more case reports describe its effectiveness in helping treat these overdoses.[9,10] The exact mechanism behind HDI therapy is still unknown

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