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Besides, exercise, diet and exogenous NO supplementation have been shown to increase NO bioavailability [152]

In addition, amylin aggregates have been detected in extra-pancreatic sites and have been linked to cerebrovascular pathology and Alzheimer's disease pathology in observational and mechanistic studies, suggesting a possible pathophysiological overlap between T2D and neurodegeneration

These findings suggest that encapsulation enhances the bioactivity, solubility, and permeability of polyphenols by increasing their bioavailability

Adding a GLP-1 RA can be more complex for those on a multiple daily injection (MDI) insulin regimen (basal + bolus)