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Furthermore, an interventional clinical trial revealed recently the amelioration of AAC was not followed by an increase or decrease in the sKlotho level in MHD patients with secondary hyperparathyroidism, which further challenged the clinical value of sKlotho in VC (Chou et al., 2019) The inconsistent studies were summarized and the average score was 6.6 stars, as shown in Table 4

The researchers found statistically significant lower rates for 10 of the 14 cancers, and no significant increase in any cancer