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Structural superposition of apo and DPA-bound Pa DHDPR revealed that the two conformations were highly similar, with a root-mean-square deviation of 0.54 (over 244 C atoms) (Fig

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Among 17 outcome estimates, 6 reported significant reductions

While no formal interaction study with minoxidil exists, the theoretical concern is that sudden, high systemic levels of a reducing agent could transiently alter the redox environment of hepatocytes, potentially affecting drug metabolism rates in unpredictable ways