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The influence of proline residues on -helical structure

Moreover, some emerging therapeutic approaches to enhance the GSH system have attracted much attention

however, Fe deficiency may complicate these findings ( Znt10 KO mice, a model of systemic Mn overload, shows that intestinal Dmt1 deficiency reduced systemic Mn accumulation, indicating that DMT1 contributes to Mn overload in these mutant mice by promoting intestinal Mn absorption (Prajapati et al., 2025)

Individuals with reduced DHFR activity are also more likely to accumulate unmetabolised folic acid when consuming high supplemental doses