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Components Absorption how the drug enters blood Distribution how the drug spreads to tissues Metabolism chemical alteration (mainly liver) Excretion removal (mainly kidney) Key parameters Bioavailability Volume of distribution (Vd) Clearance Half-life (t) Examples Oral propranolol has low bioavailability (first-pass metabolism) Renal failure reduced drug excretion Pharmacodynamics (PD) What the drug does to the body Definition Study of biochemical and physiological effects of drugs and their mechanism of action

Management of diabetes in pregnancy: Standards of Care in Diabetes2024

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signs of low blood sugar - dizziness, shakiness, confusion, sweating, rapid heartbeat - particularly if combining GLP-1 therapy with insulin or sulfonylurea diabetes medications