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These agents interact with DNA and reduce DNA synthesis upon exposure to UVA, leading to reduced proliferation of skin cells (Stern 2007)

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Additional preclinical work published in Cell Chemical Biology evaluated NNMT inhibition in similar diet-induced obesity models and confirmed the pattern: significant reductions in body weight gain, adipose tissue expansion, and circulating triglycerides compared to untreated controls

IL-1 treatment significantly decreased stress fibers within ECs but increased branched actin filaments