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Here is how the two formats compare clinically: Do GLP-1 Medications Cause Muscle Loss

Tirzepatide: A dual-action medication that targets both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

As a result, youre likely to feel satisfied with less food, which can lead to a lower calorie intake and support sustained weight loss

Notably, tirzepatide is characterised in the literature as an imbalanced or biased dual agonist: its affinity for the GIP receptor is comparable to native GIP, while its affinity for the GLP-1 receptor is roughly 18- to 20-fold weaker than native GLP-1