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Persistent tiredness and fatigue Weakness or muscle fatigue A pale or slightly yellow tint to the skin A sore or inflamed tongue Pins and needles or numbness in the hands or feet Difficulty with memory or concentration Low mood or irritability Who Needs a Vitamin B12 Injection

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That thyroid caution traces back to an FDA boxed warning

Thus, resistance to anti-VEGF drugs in advanced-stage breast cancer may be explained by the dominance of FGF-2 and other pro-angiogenic factors in such stage of the disease (Schneider and Miller, 2005)