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Abstract Alzheimers disease (AD) stands as the predominant form of dementia, presenting significant and escalating global challenges

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Paracellular and transcellular [50] substances produced by microorganisms, including short-chain fatty acids and 4-ethylphenylsulfate, travel through the portal circulation and have an impact on the immune system, metabolism, and nerve cells in the gut's enteric nervous system, as well as on the vagus nerve's afferent fibers [51]

All things considered, this leads us to wonder if this whole glutathione + citrulline idea is simply just a dead end when it comes to actual human performance