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This effect is attributed to the peptides proposed capacity to augment growth hormone secretion and subsequently elevate IGF-1 levels, a purported mediator of anabolic actions

Cohort 2 (Prevalent GLP-1 RA Users) Cohort 2 members comprised the following categories of patients: prior GLP-1 RA users who switched from other GLP-1 RAs to dulaglutide or semaglutide during the patient selection time window (prior GLP-1 RA user but nave to dulaglutide and/or semaglutide) and prior users of dulaglutide and semaglutide who received dulaglutide or semaglutide during the patient selection window (prior GLP-1 RA user not nave to dulaglutide and/or semaglutide)

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Our approach emphasizes patient education, careful patient selection, continuous clinical monitoring, and robust communication regarding risks and benefits