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Description

Any GI side effects that were present in the first four weeks tend to lessen during this phase as the body adapts to the compound

The nausea usually goes away first

Another study has demonstrated that diapocynin exhibits a lower IC 50 for NOX2 inhibition (sub-micromolar) compared to parent apocynin, effectively blocking p47^phox^ translocation and attenuating endothelial superoxide generation in isolated vessel assays (Thannickal et al., 2023)

An overview of major safety and efficacy clinical trials is provided in Tables 1, 2, 3, and 4 to bring context to the mechanistic findings reported herein