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For a 38-year-old with newly diagnosed type 2 diabetes and a family history of premature coronary disease, this guideline may favor semaglutide over older sulfonylureas or DPP-4 inhibitors even as first injectable therapy
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or the tumor is any size and cancer has spread from the thyroid to soft tissue under the skin, the esophagus, the trachea, the larynx, the recurrent laryngeal nerve (a nerve that goes to the larynx), or tissue in front of the spine, or has surrounded the carotid artery or the blood vessels in the area between the lungs
In contrast, GLP-1 receptor activation has consistently reduced MACE in randomized trials 26,27
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