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Importantly, phentermine and phentermine-topiramate extended-release (Qsymia) are contraindicated in hyperthyroidism and should be avoided in patients with active Graves disease, as they may worsen tachycardia and other sympathomimetic effects

This interaction results in the formation of a protein complex that effectively suppresses the ubiquitination and subsequent proteasomal degradation of the transcription factor BACH1, leading to significant stabilization of BACH1 protein levels

This is also true of some research papers

What to Expect from a Professional Peptide Therapy Process A well-designed program is not a one-size-fits-all solution