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A variational principle (see the Supplementary) in conjunction with the elimination of h = 1 c 14,15 leads to a Darcy law for the velocity of the cancerous phase : where ( c ) is the derivative of the free-energy of cancerous cell-cell interactions with respect to c

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Special Populations and Implementation Gaps In older or frail individuals, treatment burden, tolerability, and goals of care should be considered, but age or frailty alone should not preclude therapy