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Interestingly, the enzymatic machinery required for the local processing of GLP-1 was also detected and appeared to be sensitive to diet-induced obesity: mRNAs encoding prohormone-convertase 1/3 ( Pcsk1 ) and dipeptidyl peptidase-4 ( Dpp4 ) were identified and significantly increased in WD mice compared to RD mice (Fig

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The combination can significantly reduce appetite and caloric intake, which, if not carefully managed, may lead to dehydration, fatigue, or low blood pressure particularly in individuals also taking antihypertensive medications

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