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Thus, the drug reservoir may not be able to provide the entire dose In vivo

Pfizer said it tested four formulations of the drug to determine which might be most effective, but didnt disclose which worked best, just saying one showed the most favorable profile. Candidly, todays trial never answered the question on what once-daily modified release dose would get to competitive efficacy, Raffat said in a note to investors

10.1111/bcp.14063 Br

Both medications are contraindicated or require strict precautions in pregnancy, with topiramate now requiring a Pregnancy Prevention Programme for women of childbearing potential