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The freeze-dried format helps maintain product integrity during storage and transportation

As a reaction to the high variability in intrapatient trough levels, which are associated with worse outcomes (124129), once-daily administered Tac formulations with prolonged drug release have been developed to improve bioavailability and adherence as well as lower intraday fluctuation and peak concentrations (Cmax), as illustrated in Figure 1

A significant portion of potent herbal extracts are lipophilic (oil-soluble), making them difficult to dissolve in the standard aqueous saline used in traditional drops [350,351,352]

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