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Perkovic V, Tuttle KR, Rossing P, et al

These associations were predominantly established based on responses to antidepressant drugs and alterations in BDNF levels and neurogenesis in depressive patients or animal models for depressive behavior

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Therefore, the downstream response blocked by MC4R deficiency could affect the anorexigenic effect of the GLP-1analog, but its effect has not been confirmed yet