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3.5 Modern pharmacological approach The contemporary pharmacologic framework for DKD emphasizes the use of four core medication classes, each contributing distinct yet complementary cardiorenal protective effects

This is more physiologically appropriate and likely explains why the combination of PTD-DBM (upstream release) with valproic acid (downstream activation) produces synergistic rather than merely additive effects

1d), with larger antibiotic concentrations typically resulting in earlier condensation (Supplementary Movies 2 and 3)