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Alterations in the Firmicutes and Bacteroidetes (F/B) ratioa key marker of gut dysbiosis, have been reported in PTSD model rodents, exposed to psychological trauma using Repeated Social Defeat Stress and Single Prolonged Stress (SPS

doi: 10.3389/fphar.2024.1506767 Received 06 October 2024 Accepted 20 November 2024 Published 28 November 2024 Volume 15 - 2024 Edited by Vijay Suppiah, University of South Australia, Australia Reviewed by Salvador F

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The phosphoinositide 3-kinase (PI3K) class of intracellular enzymes is involved in multiple cell signaling pathways, including the well-studied PI3K-Akt pathway, and is involved in various cellular functions, such as cell growth, proliferation, and differentiation [15]