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However, some of the major issues with these potentially game-changing therapeutic agents include their short lifespan within the body (they are prone to hydrolysis and enzymatic degradation) and their poor oral bioavailability, which is often between 1 and 2 percent

Thyroid-gut-Axis: how does the microbiota influence thyroid function

The most commonly affected area is the terminal ileum (ileitis or regional enteritis), but the disease frequently extends into the colon (ileocolitis)