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However, this large number warrants important context: 35 of the 36 studies included in the systematic review were preclinical (conducted in laboratory or animal models), and only one clinical study met the review's inclusion criteria
Common reasons include: Pernicious anemia , an autoimmune condition affecting intrinsic factor production Gastrointestinal disorders, such as Crohns disease or celiac disease Prolonged use of certain medications, like proton pump inhibitors Knowing these causes helps spot at-risk people
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NAD+ acts as a cellular energy substrate
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