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5-Oxoprolinase deficiency Disease name 5-Oxoprolinase deficiency (OMIM 260005) Definition and diagnostic criteria 5-Oxoprolinase deficiency is a very rare autosomal recessive disease characterized by 5-oxoprolinuria and very heterogeneous clinical presentation (renal stone formation, enterocolitis, mental retardation, neonatal hypoglycemia, microcytic anemia and microcephaly)

Groups with Higher Needs or Risks [10] : Pregnancy & Lactation: Marginal biotin deficiency occurs in up to one-third of pregnant women and is also seen in lactating women, even with normal intake

18 At the same time, delayed mortality could enable insurers to hold investment earnings for longer periods of time