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Each administration led to a rapid and marked improvement in withdrawal symptoms, with effects lasting around 3.5 hours [9]

"Not FDA-approved" just means the FDA hasn't reviewed or signed off on its safety, efficacy, dosing, or manufacturing for people

In the locus coeruleus of young rats, those opioid peptides produce heterologous MOR desensitization with 2 adrenoreceptors in a GRK2-dependent manner but independently of its kinase activity