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The results show that overall in both control and diseased retinas, ROS generation due to photo-oxidation, quantified by r , drives large changes in the level of the [GSH]/[GSSG] ratio, exerting a negative effect, which indicates that this process is potentially a great contributor to increased oxidative stress
C.KopinI
Employing HITI for in vivo knock-in of large DNA fragments, we designed a guide RNA (gRNA) targeting exon 14 of the Alb gene (sgAlb-E14), which has demonstrated efficient ectopic gene integration via genome editing 20
Insulin signaling impairment in the brain as a risk factor in alzheimers disease
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