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Immune cells use ROS to sustain their functions and need adequate levels of antioxidant defenses to avoid harmful effects caused by excessive ROS production, since accurate balance between ROS and intracellular antioxidants is essential for a normal function of the cell (Banjac et al., 2008

Accordingly, we designed five 1,2-dithiolane-based prodrugs (i.e., S-CPT, S1-SN38, S2-SN38, S1-Gem, and S-PTX) with hydroxyl-based drugs as leaving groups

10.1002/jso.21106 50 PatilS.KhandelwalS.MaheshwariS

With age or factors such as poor diet, strenuous exercise, being overweight and certain health conditions, the amount of glutathione in our body decreases