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GLP-1 medications that have been frozen should be discarded immediately and not used, even after thawing

Imaeda says

That's a reason to keep on top of your nutrition and strength-training while on these drugs, he writes, "especially for older people like me, who are [already] susceptible to muscle loss." There are people who should steer clear of GLP-1 drugs, Kessler notes, including those with a personal or familial history of certain thyroid and endocrine cancers, those with chronic kidney disease, pancreatitis, inflammatory bowel diseases, uncontrolled diarrhea or constipation or gastroparesis, or if you are pregnant

There isnt strong proof that GLP-1 medicines directly cause DME, but its something doctors keep an eye on