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A landmark brain imaging study using proton magnetic resonance spectroscopy (1H MRS) revealed a staggering 36% decrease in cortical glutathione levels in the brains of ME/CFS patients compared to healthy controls

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Further research is needed to elucidate the circumstances, specific molecular targets, other enzymes involved in the signaling process, and to map the involvement of GSH in redox signaling pathways ( An emerging area of research is that of immune memory in the brain ( Because of the importance of GSH in many cellular and immunological processes and its potential as a biomarker, accurate measurement and analysis of GSH levels are critical to further research and analysis of its efficacy as a treatment