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PMID: 29155147): 5-Amino-1MQ showed NNMT selectivity with IC50 of 1.2 microM Reduced body weight and white adipose mass in diet-induced obese mice over 11 days No effect on food intake, suggesting metabolic rather than appetitive mechanism Nicotinamide N-methyltransferase inhibition mimics and boosts exercise-mediated improvements in muscle function in aged mice , published in Scientific Reports (Dimet-Wiley AL et al., 2024

Ce dernier se produit gnralement lorsque des espces ractives de l'oxygne, galement connues sous le nom de sous-produits nocifs du mtabolisme, s'accumulent et affectent l'ADN, les protines et les lipides

doi: 10.1186/1471-230X-11-7 109

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