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They reveal that the response distribution is biologically heterogeneous in ways the field is only beginning to map, and that the current pharmacological approach a single receptor axis, maximum tolerated dose, dosed until plateau appears to be approaching the ceiling of what that mechanism can achieve for a substantial fraction of patients

The collective preclinical results have now been translated into Phase I clinical trials in patients with myelodysplastic syndromes

Laboratory studies in some adult tumors and in neuroblastoma have shown that sometimes BSO needs to be combined with higher doses of melphalan to kill more cancer cells

Kearns-Sayre syndrome with reduced plasma and cerebrospinal fluid folate