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Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one

MBX 4291, dual GLP-1/GIP co-agonist prodrug designed for potential once-monthly dosing and improved tolerability in obesity Recent Highlights: In June 2026, MBX Biosciences announced data that demonstrated sustained benefit of its once-weekly Canvuparatide as a potential PTH replacement therapy in chronic hypoparathyroidism

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Hall Jan 2022)