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Int J Mol Med 38:776784 Dahan S, Rabinowitz KM, Martin AP, Berin MC, Unkeless JC, Mayer L (2011) Notch-1 signaling regulates intestinal epithelial barrier function, through interaction with CD4 + T cells, in mice and humans

Further studies revealed that IGF-1 activates the inflammatory signals NF-B and NLRP3 in cancer cells and that this activation depends on the accumulation of ROS and NOX2