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In the liver, MAPK regulates lipid metabolism by phosphorylating target enzymes, promoting fatty acid oxidation through the inactivation of ACC and the activation of malonyl-CoA decarboxylase (MCD) (Zhao et al., 2022a)

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SGLT-2 inhibitors cause robust reduction of HHF and the renal outcome, and moderate reduction of CV or total deaths and MACE [13]