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The most commonly reported effects include: Nausea, especially after starting treatment or increasing the dose Vomiting or stomach discomfort Diarrhea or constipation Reduced appetite and lower calorie intake For many people, these symptoms improve as the body adjusts over the first few weeks

Among newer entrants, KPV (gut health), GHK-Cu (cosmetic crossover), and MOTS-c (longevity) show the sharpest 2026 growth from smaller bases

Some patients successfully transition to lower doses that prevent weight regain without the side effects of higher therapeutic doses

Over-the-counter topical anesthetics like lidocaine cream can be applied 15 to 20 minutes before injection to reduce needle pain, though they do not prevent burning from the medication itself