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Studies which make use of phosphocreatinine/creatinine for this purpose may suffer from methodological error given the reported negative association between creatinine levels and depression scores (Faulkner et al

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These findings highlighted that ultrahigh-dose methylcobalamin was efficacious in slowing functional decline in patients with early-stage ALS and with moderate progression rate and was safe to use during the 16-week treatment period, the researchers wrote

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