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In the nucleus PP2A dephosphorylates Thr666 which allows ChREBP to bind to specific sequence elements (ChoRE) in target genes

Oncogene 18 : 41084119

In 2023, a randomized, double-blind, placebo-controlled, multicenter trial investigated the efficacy of tirzepatide over 24 weeks in patients with moderate-to-severe obesity and OSAS

Those taking the meds noted specific gains when it came to mobility, self-care, and how easily they could perform their usual activities