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Thus, in the course of aging various potentially pathogenic mechanisms, including the increase in oxidative damage, could on the one hand influence the quality of aging and on the other favour the onset and evolution of a definite neurodegenerative disease

The latter are dependent on the generation of nicotinamide adenine dinucleotide phosphate (NADPH), which is used to maintain reduced glutathione (GSH) and thioredoxin (TRX)

Further novel treatments include lasting modulation through gene therapy of the NO system, which affects penile musculature to enable erectile response