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Already, many GLP-1 users quit within a year, studies suggest -- often due to side effects, high costs, or insurance issues

Some people find success with an approach called split dosing , where they divide their weekly dose into two injections given 3 to 4 days apart

In research settings, this peptide combination is often described as well tolerated , with potential side effects including mild fluid retention, headache, and temporary injection-site irritation