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Cell growth, controlled by sodium-hydrogen ion exchangers (NHEs), induces MIC-dependent activation of the PI3K/Akt pathway, which in turn supports the cytoplasmic localization of the cell cycle inhibitor p27 Kip1 , resulting in tumor cell proliferation [142]

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For instance, extracts from Guizhi Fuling Pills and Paeonia bark gum (Baikejiao) have been reported to downregulate transferrin receptor 1 (TfR1) and upregulate ferroportin 1 (FPN1) expression, thereby facilitating the restoration of intracellular and extracellular iron equilibrium (Liu R

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