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10.1093/eurheartj/ehaa207 20 LiuM.LiN.LuX.ShanS.GaoX.CaoY.et al (2022)

Though these findings were heterogeneous, there was no added benefit of liraglutide and its use therefore in clinical practice for this given population is not supported [95]

It reflects the combined stability data for the peptide itself and the preservative activity of the benzyl alcohol in bacteriostatic water

Abbreviations SMA alpha smooth muscle actin AD Alzheimers disease AI Artificial intelligence A Amyloid- Aib -aminoisobutyric acid AAV Adeno-associated virus AuNPs gold NPs APP Amyloid precursor protein A 142 42-amino-acid amyloid-beta isoform ALS Amyotrophic lateral sclerosis Apoe/ Apolipoprotein E knockout Ach Acetylcholine ANP Atrial natriuretic peptide APP/PS1 mice Amyloid precursor protein/presenilin 1 mice ABC Accelerated blood clearance AMF Alternating magnetic fields AGILE AI-guided Ionizable lipid engineering BM-MSCs Bone marrow-derived mesenchymal stem cells BAT Brown adipose tissue BACE1 -secretase 1 BV2 Mouse microglial cell line bEnd.3 Mouse brain endothelial cells BSA Bovine serum albumin CMC Chemistry, manufacturing, and controls COPD Chronic obstructive pulmonary disease Col Collagen CRP C-reactive protein CtrlNP Control NP CVD Cardiovascular diseases Cy5.5 Cyanine 5.5 CXCR4 C-X-C motif chemokine receptor 4 CNS Central nervous system cryo-EM cryo-electron microscopy cAMP cyclic adenosine monophosphate DPP-4 Dipeptidyl peptidase-4 DSPC 1,2-distearoyl-sn-glycero-3-phosphocholine dPA dehydro-palmitoylated DN Diabetic nephropathy DLS Dynamic light scattering DFO Deferoxamine DDM n-dodecyl--D-maltoside DPPC Dipalmitoylphosphatidylcholine DP Diabetic periodontitis DMG-PEG 1,2-dimyristoyl-rac-glycero-3-methoxypolyethylene glycol Epac Exchange protein directly activated by cAMP E